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Article

Alterations in Brca1 expression in mouse ovarian granulosa cells have short-term and long-term consequences on estrogen-responsive organs.

Laboratory investigation; a journal of technical methods and pathology - 1 Jun 2012

Yen Hai-Yun, Gabet Yankel, Liu Ying, Martin Anthony, Wu Nancy L, Pike Malcolm C, Frenkel Baruch, Maxson Robert, Dubeau Louis

Abstract excerpt

Incessant menstrual cycle activity, uninterrupted by either pregnancy or oral contraceptive use, is the most important risk factor for sporadic ovarian cancer. Menstrual cycle progression is partly controlled by steroid hormones such as estrogens and others that are secreted by the ovarian granulosa cells. We showed earlier that mice carrying a homozygous granulosa cell-specific knockout of Brca1, the homolog of...

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Source

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Identifiers

PMID: 22488153
DOI: 10.1038/labinvest.2012.58
PMCID: PMC4530993

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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