Article
Chronic estrus disrupts uterine gland development and homeostasis
2018-06-15
Abstract excerpt
Female mice homozygous for an engineered Gnrhr E90K mutation have reduced gonadotropin-releasing hormone signaling, leading to infertility. Their ovaries have numerous antral follicles but no corpora lutea, indicating a block to ovulation. These mutants have high levels of circulating estradiol and low progesterone, indicating a state of persistent estrus. This mouse model provided a unique opportunity to examine...
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Identifiers and source
- Literature Corpus work
- 3fe1f13b-e964-5e51-af28-d4fa5598c7c3
- DOI
- 10.1101/347757