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Article

The short estrous cycle of mice may influence the effect of BRCA1 mutations.

Medical hypotheses - 1 Sept 2011

Nishimura Toshihide

Abstract excerpt

Breast and ovarian cancer susceptibility gene 1 (BRCA1) was identified from the genomic analysis of breast cancer families. Women heterozygous for a germ line mutation in the BRCA1 gene have a high risk of developing breast or ovarian cancers. BRCA1-mutant mice were created to study the function of BRCA1, but the heterozygous mice were healthy. The reason for this difference in phenotype between mice and humans...

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Identifiers

PMID: 21684693
DOI: 10.1016/j.mehy.2011.05.029

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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