Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wt1 functions in ovarian follicle development by regulating granulosa cell differentiation

5 Sept 2013

Abstract excerpt

The Wt1 gene encodes a nuclear transcription factor that is specifically expressed in ovarian granulosa cells. However, the physiological significance of Wt1 in ovarian follicle development remains elusive. In this study, we found that Wt1(+/R394W) mice were grossly normal, however, the females displayed severe reproductive defects. Only ∼15% of the Wt1(+/R394W) females became pregnant after mating with wild-type...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pluripotent Stem Cells Research
Share to Renal and related cancers
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24009315
DOI: 10.1093/hmg/ddt423

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wt1 functions in ovarian follicle development by regulating granulosa cell differentiationPMID 24009315Read ↗

Inactivation of Wt1 causes pre-granulosa cell to steroidogenic cell transformation and defect of ovary development†Semantic proximity Read ↗

Novel WT1 Missense Mutations in Han Chinese Women with Premature Ovarian Failure.Semantic proximity Read ↗

The functions of Wt1 in mouse gonad development and somatic cells differentiationSemantic proximity Read ↗

Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cellsSemantic proximity Read ↗

GDF9His209GlnfsTer6/S428T and GDF9Q321X/S428T bi-allelic variants caused female subfertility with defective follicle enlargementSemantic proximity Read ↗

Impaired follicle development and infertility in female mice lacking steroidogenic factor 1 in ovarian granulosa cells.Semantic proximity Read ↗

CPEB3 deficiency in mice affect ovarian follicle development and causes premature ovarian insufficiency.Semantic proximity Read ↗

Single-cell RNA-seq identified novel genes involved in primordial follicle formationSemantic proximity Read ↗

miR-29a/b1 Regulates the Luteinizing Hormone Secretion and Affects Mouse Ovulation.Semantic proximity Read ↗

Granulosa cell-specific FOXJ2 overexpression induces premature ovarian insufficiency by triggering apoptosis via mitochondrial calcium overloadSemantic proximity Read ↗

DPAGT1‐Mediated Protein N‐Glycosylation Is Indispensable for Oocyte and Follicle Development in MiceSemantic proximity Read ↗

<em>lima1a</em> Promotes Germ Cell Development and Ovary-to-Testis Transition Via Maintaining EMT in Gonadal CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.