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Article

Identifying genes for alcohol and drug sensitivity: recent progress and future directions.

Trends in neurosciences - 1 Apr 1999

Crabbe J C, Phillips T J, Buck K J, Cunningham C L, Belknap J K

Abstract excerpt

New methods for identifying chromosomal regions containing genes that affect murine responses to alcohol and drugs have been used to identify many provisional quantitative trait loci (QTLs) since 1991. By 1998, 24 QTLs had been definitively mapped (P<5x10(-5)) to specific murine chromosomes, which indicates the presence of a relevant gene or genes at each location. The syntenic (homologous) region of the human...

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PMID: 10203855
DOI: 10.1016/s0166-2236(99)01393-4

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