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Article

Methionine scanning as an NMR tool for detecting and analyzing biomolecular interaction surfaces.

Structure (London, England : 1993) - 4 Apr 2012

Stoffregen Mira C, Schwer Matthias M, Renschler Fabian A, Wiesner Silke

Abstract excerpt

Methyl NMR spectroscopy is a powerful tool for studying protein structure, dynamics, and interactions. Yet difficulties with resonance assignment and the low abundance of methyl groups can preclude detailed NMR studies, particularly the determination of continuous interaction surfaces. Here we present a straightforward strategy that overcomes these problems. We systematically substituted solvent-exposed residues...

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PMID: 22483105
DOI: 10.1016/j.str.2012.02.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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