Article
COOH-terminal 26-amino acid residues of progastrin are sufficient for stimulation of mitosis in murine colonic epithelium in vivo.
American journal of physiology. Gastrointestinal and liver physiology - 1 Mar 2005
Ottewell P D, Varro A, Dockray G J, Kirton C M, Watson A J M, Wang T C, Dimaline R, Pritchard D M
Abstract excerpt
Transgenic mice (hGAS) that overexpress human progastrin are more susceptible than wild-type mice (FVB/N) to the induction of colonic aberrant crypt foci (ACF) and adenomas by the chemical carcinogen azoxymethane. We have previously shown significantly increased levels of colonic mitosis in hGAS compared with FVB/N mice after gamma-radiation. To investigate whether the effects of progastrin observed in hGAS colon...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.