Article
Flotillin-1 regulates oncogenic signaling in neuroblastoma cells by regulating ALK membrane association.
Cancer research - 15 Jul 2014
Tomiyama Arata, Uekita Takamasa, Kamata Reiko, Sasaki Kazuki, Takita Junko, Ohira Miki, Nakagawara Akira, Kitanaka Chifumi, Mori Kentaro, Yamaguchi Hideki, Sakai Ryuichi
Abstract excerpt
Neuroblastomas harbor mutations in the nonreceptor anaplastic lymphoma kinase (ALK) in 8% to 9% of cases where they serve as oncogenic drivers. Strategies to reduce ALK activity offer clinical interest based on initial findings with ALK kinase inhibitors. In this study, we characterized phosphotyrosine-containing proteins associated with ALK to gain mechanistic insights in this setting. Flotillin-1 (FLOT1), a...
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