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Article

Mutation screening of RAD51C in high-risk breast and ovarian cancer families.

Familial cancer - 1 Sept 2012

Lu Wenping, Wang Xianshu, Lin Hongsheng, Lindor Noralane M, Couch Fergus J

Abstract excerpt

Deleterious mutations in the RAD51C gene, which encodes a DNA double-strand break repair protein, have been reported to confer high-penetrance susceptibility to both breast and ovarian cancer. To confirm this we conducted a mutation screen of the RAD51C gene in 192 probands from high-risk breast and/or ovarian cancer families that do not carry BRCA1 or BRCA2 mutations. The nine exons of the RAD51C gene containing...

Topics

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BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
Cohort Studies
DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation, Missense

Ovarian Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 22476429
DOI: 10.1007/s10689-012-9523-9
PMCID: PMC3418444

Genes

BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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