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Article

A HRM-based screening method detects RAD51C germ-line deleterious mutations in Spanish breast and ovarian cancer families.

Breast cancer research and treatment - 1 Oct 2011

Romero Atocha, Pérez-Segura Pedro, Tosar Alicia, García-Saenz José Angel, Díaz-Rubio Eduardo, Caldés Trinidad, de la Hoya Miguel

Abstract excerpt

The RAD51C gene has been recently proposed as a high-penetrance breast and ovarian cancer gene. However, early replication studies have failed to confirm the finding. Thus, further studies in larger cohorts should be conducted in order to clarify the role of RAD51C as a cancer susceptibility gene. Here, we describe a high-resolution melting analysis (HRMA)-based method developed for presequence screening of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21537932
DOI: 10.1007/s10549-011-1543-x

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A HRM-based screening method detects RAD51C germ-line deleterious mutations in Spanish breast and ovarian cancer families.PMID 21537932Read ↗

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Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patientsSemantic proximity Read ↗

Evaluation of RAD51C as cancer susceptibility gene in a large breast-ovarian cancer patient population referred for genetic testing.Semantic proximity Read ↗

About 1% of the breast and ovarian Spanish families testing negative for BRCA1 and BRCA2 are carriers of RAD51D pathogenic variants.Semantic proximity Read ↗

Identification of six pathogenic RAD51C mutations via mutational screening of 1228 Danish individuals with increased risk of hereditary breast and/or ovarian cancer.Semantic proximity Read ↗

RAD51C mutation screening in high-risk patients from Serbian hereditary breast/ovarian cancer families.Semantic proximity Read ↗

Mutation analysis of RAD51L1 (RAD51B/REC2) in multiple-case, non-BRCA1/2 breast cancer families.Semantic proximity Read ↗

Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients.Semantic proximity Read ↗

A decade of RAD51C and RAD51D germline variants in cancer.Semantic proximity Read ↗

Mutational analysis of RAD51C and RAD51D genes in hereditary breast and ovarian cancer families from Murcia (southeastern Spain).Semantic proximity Read ↗

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