Article
Importance of DNA repair in tumor suppression.
Physical review. E, Statistical, nonlinear, and soft matter physics - 1 Dec 2004
Brumer Yisroel, Shakhnovich Eugene I
Abstract excerpt
The transition from a normal to cancerous cell requires a number of highly specific mutations that affect cell cycle regulation, apoptosis, differentiation, and many other cell functions. One hallmark of cancerous genomes is genomic instability, with mutation rates far greater than those of normal cells. In microsatellite instability (MIN tumors), these are often caused by damage to mismatch repair genes,...
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