Article
Epistasis and its relationship to canalization in the RNA virus phi 6.
Genetics - 1 Jun 2004
Burch Christina L, Chao Lin
Abstract excerpt
Although deleterious mutations are believed to play a critical role in evolution, assessing their realized effect has been difficult. A key parameter governing the effect of deleterious mutations is the nature of epistasis, the interaction between the mutations. RNA viruses should provide one of the best systems for investigating the nature of epistasis because the high mutation rate allows a thorough...
Topics
- Bacteriophage phi 6
- Epistasis, Genetic
- Genotype
- Mutation
- Pseudomonas syringae
- RNA Viruses
- Virus Replication