Increased rate of base substitution in a hamster mutator strain obtained during serial selection for gene amplification.

doi:10.1128/mcb.10.12.6805-6808.1990

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Article

Increased rate of base substitution in a hamster mutator strain obtained during serial selection for gene amplification.

Molecular and cellular biology - 1 Dec 1990

Caligo M A, Armstrong W, Rossiter B J, Meuth M

Abstract excerpt

The pattern of mutations produced by a mutator gene (obtained during serial selection for amplification of the dihydrofolate reductase [dhfr] locus) shows a pronounced shift from that found in wild-type cells. The rate of certain types of base substitutions (particularly transitions) is dramatically increased, while gene rearrangements constitute a lower proportion of mutations. These data suggest a lower...

Topics

Animals
Base Sequence
Cell Line
Chromosome Deletion
Cricetinae
Drug Resistance
Gene Amplification
Methotrexate
Molecular Sequence Data
Mutation
Tetrahydrofolate Dehydrogenase

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