Article
Impact of intestinal CYP2C19 genotypes on the interaction between tacrolimus and omeprazole, but not lansoprazole, in adult living-donor liver transplant patients.
Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2009
Hosohata Keiko, Masuda Satohiro, Katsura Toshiya, Takada Yasutsugu, Kaido Toshimi, Ogura Yasuhiro, Oike Fumitaka, Egawa Hiroto, Uemoto Shinji, Inui Ken-ichi
Abstract excerpt
To assess the effects of intestinal cytochrome P450 2C19 on the interaction between tacrolimus and proton pump inhibitors, we examined the concentration/dose ratio [(ng/ml)/(mg/day)] of tacrolimus coadministered with omeprazole (20 mg) or lansoprazole (30 mg) to 89 adult living-donor liver transplant patients on postoperative days 22 to 28, considering the CYP2C19 genotypes of the native intestine and the graft...
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