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Article

Individual metabolic capacity evaluation of cytochrome P450 2C19 by protein and activity in the small intestinal mucosa of Japanese pancreatoduodenectomy patients.

Biological & pharmaceutical bulletin - 1 Jan 2011

Hayashi Mikihito, Matsumoto Naoki, Takenoshita-Nakaya Sachiko, Takeba Yuko, Watanabe Minoru, Kumai Toshio, Takagi Masayuki, Tanaka Masami, Otsubo Takehito, Kobayashi Shinichi

Abstract excerpt

Some P450 enzymes are expressed not only in the liver but also in the small intestine, and these enzymes play an important role in first-pass drug metabolism in the small intestine. Cytochrome P450 (CYP)2C19 has been confirmed to exist in the small intestine of white people, but not yet in Japanese. We investigated the mRNA level, protein level, and activity of CYP2C19 in the small intestine in a Japanese...

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Identifiers

PMID: 21212520
DOI: 10.1248/bpb.34.71

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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