Article
miR-1322 regulates ChREBP expression via binding a 3'-UTR variant (rs1051943).
Journal of cellular and molecular medicine - 1 Nov 2018
Zhang Ying, Hu Sen-Lin, Hu Dong, Jiang Jian-Gang, Cui Guang-Lin, Liu Xing-De, Wang Dao Wen
Abstract excerpt
The carbohydrate response element-binding protein (ChREBP), also referred to as MLXIPL, plays a crucial role in the regulation of glucose and lipid metabolism. Existing studies have shown an association between genetic variations of the ChREBP gene and lipid levels, such as triglycerides and high-density lipoprotein cholesterol. However, mechanistic studies of this association are limited. In this study,...
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