Article
Using ChIP-based technologies to identify epigenetic modifications in disease-relevant cells.
IDrugs : the investigational drugs journal - 1 Mar 2010
Falk Jeffrey
Abstract excerpt
The effect of epigenetic modifications on the regulation of gene expression and the concomitant relationship to human diseases has become a key area of biological research in recent years. Studies have suggested that there is direct correlation between epigenetic modifications, such as histone methylation, histone acetylation and DNA methylation, and gene expression in disease-relevant cells, including cancer...
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