Article
The cannabinoid receptor type 2 Q63R variant increases the risk of celiac disease: implication for a novel molecular biomarker and future therapeutic intervention.
Pharmacological research - 1 Jul 2012
Rossi Francesca, Bellini Giulia, Tolone Carlo, Luongo Livio, Mancusi Silvia, Papparella Alfonso, Sturgeon Craig, Fasano Alessio, Nobili Bruno, Perrone Laura, Maione Sabatino, del Giudice Emanuele Miraglia
Abstract excerpt
Celiac disease (CD) is a chronic inflammatory disease of the small bowel that occurs with the ingestion of gluten, found in several grains products. Although HLA-DQ2 variant is required for the gluten-derived peptide gliadin presentation by antigen-presenting cells to T-cells, non-HLA genetic factors account for the majority of heritable risk. Several genome-wide association studies have identified susceptibility...
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