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Article

What would 5-HT do? Regional diversity of 5-HT(1) receptor modulation of primary afferent neurotransmission.

British journal of pharmacology - 1 Sept 2012

Connor Mark

Abstract excerpt

5-HT (serotonin) is a significant modulator of sensory input to the CNS, but the only analgesics that selectively target G-protein-coupled 5-HT receptors are highly specific for treatment of headache. Two recent papers in BJP shed light on this puzzling situation by showing that primary afferent neurotransmission to the superficial layers of the spinal and trigeminal dorsal is inhibited by different subtypes of...

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Identifiers

PMID: 22462412
DOI: 10.1111/j.1476-5381.2012.01963.x
PMCID: PMC3481042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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