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Article

Exploring Pain Phenotyping in Cervicogenic Headache Management.

Current pain and headache reports - 13 Dec 2025

Cropes Michael, Deacon Albojay, Nelson Evan O, Deuel Daniel, Sandgren Andrew, Abd-Elsayed Alaa, Houdek Tiffany

Abstract excerpt

PURPOSE OF REVIEW: Intervention trials for cervicogenic headache (CGH) often yield equivocal results with marked treatment effect heterogeneity, possibly reflecting variations in underlying pain mechanisms throughout the CGH population. Pain phenotyping or classifying patients into subgroups based on their predominant pain mechanism may facilitate more precise CGH treatment. This review aims to explore the role...

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PMID: 41389321
DOI: 10.1007/s11916-025-01420-0
PMCID: PMC12701865

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