Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hepatocyte growth factor gene therapy enhances infiltration of macrophages and may induce kidney repair in db/db mice as a model of diabetes

29 Mar 2012

Abstract excerpt

AIMS/HYPOTHESIS: We previously demonstrated hepatocyte growth factor (HGF) gene therapy was able to induce regression of glomerulosclerosis in diabetic nephropathy through local reparative mechanisms. The aim of this study was to test whether bone-marrow-derived cells are also involved in this HGF-induced reparative process. METHODS: We have created chimeric db/db mice as a model of diabetes that produce enhanced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Kidney Disease and Diabetes
Share to Liver physiology and pathology
Share to Renal and related cancers

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22460762
DOI: 10.1007/s00125-012-2535-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hepatocyte growth factor gene therapy enhances infiltration of macrophages and may induce kidney repair in db/db mice as a model of diabetesPMID 22460762Read ↗

Bone marrow transplantation induces normoglycemia in a type 2 diabetes mellitus murine model.Semantic proximity Read ↗

Myofibroblast progenitor cells are increased in number in patients with type 1 diabetes and express less bone morphogenetic protein 6: a novel clue to adverse tissue remodelling?Semantic proximity Read ↗

Reciprocal balance of hepatocyte growth factor and transforming growth factor-beta 1 in renal fibrosis in mice.Semantic proximity Read ↗

Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of actionSemantic proximity Read ↗

Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice.Semantic proximity Read ↗

The phenotypic fate of bone marrow-derived stem cells in acute kidney injury.Semantic proximity Read ↗

Endogenous hepatocyte growth factor ameliorates chronic renal injury by activating matrix degradation pathways.Semantic proximity Read ↗

Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis.Semantic proximity Read ↗

Electroporation-mediated HGF gene transfer ameliorated cyclosporine nephrotoxicity.Semantic proximity Read ↗

Electroporation-mediated PDGF receptor-IgG chimera gene transfer ameliorates experimental glomerulonephritis.Semantic proximity Read ↗

Constitutive expression of HGF modulates renal epithelial cell phenotype and induces c-met and fibronectin expression.Semantic proximity Read ↗

Transforming growth factor-β1 in the microenvironment of ischemia reperfusion-injured kidney enhances the chemotaxis of mesenchymal stem cells to stromal cell-derived factor-1 through upregulation of surface chemokine (C-X-C motif) receptor 4.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.