Inhibition of fibroblasts reduced head and neck cancer growth by targeting fibroblast growth factor receptor

doi:10.1002/lary.23266

Article

Inhibition of fibroblasts reduced head and neck cancer growth by targeting fibroblast growth factor receptor

27 Mar 2012

Abstract excerpt

OBJECTIVES/HYPOTHESIS: Head and neck squamous cell carcinoma (HNSCC) is a complex disease process involving interactions with carcinoma-associated fibroblasts and endothelial cells. We further investigated these relationships by suppressing stromal cell growth through the inhibition of fibroblast growth factor receptor (FGFR). STUDY DESIGN: Preclinical investigation. METHODS: HNSCC cell lines (FADU, OSC19, Cal27,...

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