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Article

Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2

5 Feb 2012

Abstract excerpt

Prostaglandin (PG)E(2) is relevant in tumor biology, and interactions between tumor and stroma cells dramatically influence tumor progression. We tested the hypothesis that cross-talk between head and neck squamous cell carcinoma (HNSCC) cells and fibroblasts could substantially enhance PGE(2) biosynthesis. We observed an enhanced production of PGE(2) in cocultures of HNSCC cell lines and fibroblasts, which was...

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PMID: 22308510
DOI: 10.1194/jlr.m019695

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