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Article

Polymorphisms in the CD3Z gene influence TCRzeta expression in systemic lupus erythematosus patients and healthy controls.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2008

Gorman Claire L, Russell Andrew I, Zhang Zhuoli, Cunninghame Graham Deborah, Cope Andrew P, Vyse Timothy J

Abstract excerpt

TCRzeta (CD247) functions as an amplification module in the TCR signaling cascade and is essential for assembly and surface expression of the TCR/CD3 complex. The TCRzeta-chain is down-regulated in many chronic infectious and inflammatory diseases, including systemic lupus erythematosus (SLE). It is unclear whether reduced TCRzeta expression is a cause or a consequence of chronic inflammatory responses. We have...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18178846
DOI: 10.4049/jimmunol.180.2.1060

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Polymorphisms in the CD3Z gene influence TCRzeta expression in systemic lupus erythematosus patients and healthy controls.PMID 18178846Read ↗

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