Expanding the clinical spectrum of CD3γ deficiency: comprehensive characterization of adult-onset disease and integrated reevaluation of all reported patients.

doi:10.3389/fimmu.2026.1889169

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Expanding the clinical spectrum of CD3γ deficiency: comprehensive characterization of adult-onset disease and integrated reevaluation of all reported patients.

Frontiers in immunology - 1 Jan 2026

Obeng Raphaela, Elsayed Abdulwahab, Takyi Amos, von Hardenberg Sandra, Atschekzei Faranaz, Witte Torsten, Sogkas Georgios

Abstract excerpt

Objective: CD3γ deficiency is an ultrarare autosomal recessive inborn error of immunity characterized by immune dysregulation and variable immunodeficiency. To date, only 16 predominantly pediatric cases have been reported. Here, we describe two additional adult patients with CD3γ deficiency and provide a comprehensive reevaluation of all previously published cases. Methods: Clinical, immunological, and genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Agammaglobulinemia
Share to Age of Onset
Share to CD3 Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunologic Deficiency Syndromes

Share to Mutation

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 42661620
DOI: 10.3389/fimmu.2026.1889169
PMCID: PMC13518112

Genes

CD3G

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.