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Article

Downregulation of CD3ζ in NK Cells from Systemic Lupus Erythematosus Patients Confers a Proinflammatory Phenotype.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2018

Suárez-Fueyo Abel, Bradley Sean J, Katsuyama Takayuki, Solomon Sarah, Katsuyama Eri, Kyttaris Vasileios C, Moulton Vaishali R, Tsokos George C

Abstract excerpt

Cytotoxic function and cytokine profile of NK cells are compromised in patients with systemic lupus erythematosus (SLE). CD3ζ, an important molecule for NK cell activation, is downregulated in SLE T cells and contributes to their altered function. However, little is known about the role of CD3ζ in SLE NK cells. We studied CD3ζ levels and its contribution to cytotoxic, degranulation, and cytokine production...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29602774
DOI: 10.4049/jimmunol.1700588
PMCID: PMC6048443

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TNF

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