Article
The cluster of miR-143 and miR-145 affects the risk for esophageal squamous cell carcinoma through co-regulating fascin homolog 1.
PloS one - 1 Jan 2012
Liu Ran, Liao Juan, Yang Miao, Sheng Jingyi, Yang Hao, Wang Yi, Pan Enchun, Guo Wei, Pu Yuepu, Kim Sun Jung, Yin Lihong
Abstract excerpt
MicroRNAs (miRNAs), 18-24 nt non-coding RNAs, are thought to play important roles in cell proliferation, differentiation, apoptosis, and development. Recent studies suggest that some of the known microRNAs map to a single genomic locale within a single polycistronic transcript. But the roles of the cluster remain to be known. In order to understand the role and mechanism of a cluster of miR-143 and miR-145 in...
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