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miR-143 and miR-145 synergistically regulate ERBB3 to suppress cell proliferation and invasion in breast cancer

23 Sept 2014

Abstract excerpt

INTRODUCTION: ERBB3, one of the four members of the ErbB family of receptor tyrosine kinases, plays an important role in breast cancer etiology and progression. In the present study, we aimed to identify novel miRNAs that can potentially target ERBB3 and their biological functions. METHOD: The expression levels of miR-143/145 and target mRNA were examined by relative quantification RT-PCR, and the expression...

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PMID: 25248370
DOI: 10.1186/1476-4598-13-220

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