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Article

A Functional Polymorphism in the Promoter of MiR-143/145 Is Associated With the Risk of Cervical Squamous Cell Carcinoma in Chinese Women: A Case-Control Study.

Medicine - 1 Aug 2015

Liang Yundan, Sun Ruifen, Li Lijuan, Yuan Fang, Liang Weibo, Wang Li, Nie Xinwen, Chen Peng, Zhang Lin, Gao Linbo

Abstract excerpt

MiR-143/145 is down-regulated in cervical cancer, which may serve as a tumor suppressor by targeting KRAS and Ras-responsive element-binding protein (RREB1). Activated KRAS leads to down-regulation of miR-143/145 transcription in a RREB1-dependent manner, establishing a miR-143/145-KRAS-RREB1 feedback loop. A polymorphism rs4705343C/T in the promoter of miR-143/145 might influence the binding of TATA-binding...

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Identifiers

PMID: 26252302
DOI: 10.1097/MD.0000000000001289
PMCID: PMC4616598

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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