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Article

miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer

16 Feb 2010

Abstract excerpt

BACKGROUND: We have recently identified down-regulated microRNAs including miR-145 and miR-133a in bladder cancer (BC). The aim of this study is to determine the genes targeted by miR-145, which is the most down-regulated microRNA in BC. METHODS: We focused on fascin homologue 1 (FSCN1) from the gene expression profile in miR-145 transfectant. The luciferase assay was used to confirm the actual binding sites of...

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Share to Bladder and Urothelial Cancer Treatments
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PMID: 20160723
DOI: 10.1038/sj.bjc.6605570

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