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Article

The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity.

Aging cell - 1 Aug 2011

Yang Christine C, Chen Diana, Lee Siu Sylvia, Walter Ludivine

Abstract excerpt

Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that...

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Identifiers

PMID: 21463460
DOI: 10.1111/j.1474-9726.2011.00711.x
PMCID: PMC3135752

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