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Article

Latent acyclovir-resistant herpes simplex virus type 1 in trigeminal ganglia of immunocompetent individuals.

The Journal of infectious diseases - 15 May 2012

van Velzen Monique, van Loenen Freek B, Meesters Roland J W, de Graaf Miranda, Remeijer Lies, Luider Theo M, Osterhaus Albert D M E, Verjans Georges M G M

Abstract excerpt

Specific mutations within the hypervariable herpes simplex virus (HSV) gene thymidine kinase (TK) gene lead to acyclovir (ACV) resistance. To uncover the existence of latent ACV-resistant (ACV(R)) HSV-1, we determined the genetic and functional variability of the HSV-1 TK gene pool in paired trigeminal ganglia (TG) of 5 immunocompetent individuals. The latent virus pool consisted of a donor-specific HSV-1...

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PMID: 22457282
DOI: 10.1093/infdis/jis237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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