Thymidine Kinase-Negative Herpes Simplex Virus 1 Can Efficiently Establish Persistent Infection in Neural Tissues of Nude Mice.

Abstract excerpt

Herpes simplex virus 1 (HSV-1) establishes latency in neural tissues of immunocompetent mice but persists in both peripheral and neural tissues of lymphocyte-deficient mice. Thymidine kinase (TK) is believed to be essential for HSV-1 to persist in neural tissues of immunocompromised mice, because infectious virus of a mutant with defects in both TK and UL24 is detected only in peripheral tissues, but not in...

Topics

• Animals
• Brain Stem
• Cell Line
• Disease Models, Animal
• Herpes Simplex
• Herpesvirus 1, Human
• Humans
• Mice
• Mice, Nude
• Mutation
• Nerve Tissue