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Article

Staphylococcus aureus activation of caspase 1/calpain signaling mediates invasion through human keratinocytes.

The Journal of infectious diseases - 15 May 2012

Soong Grace, Chun Jarin, Parker Dane, Prince Alice

Abstract excerpt

The USA300 strains of Staphylococcus aureus are the major cause of skin and soft tissue infection in the United States. Invasive USA300 infection has been attributed to several virulence factors, including protein A and the α-hemolysin (Hla), which cause pathology by activating host signaling cascades. Here we show that S. aureus exploits the proinflammatory bias of human keratinocytes to activate pyroptosis, a...

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Identifiers

PMID: 22457275
DOI: 10.1093/infdis/jis244
PMCID: PMC3415815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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