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Staphylococcus aureus β-hemolysin causes skin inflammation by acting as an agonist of epidermal growth factor receptor

7 Dec 2023

Abstract excerpt

ABSTRACT Staphylococcus aureus is a common cause of inflammatory skin diseases, with one of its virulence factors, β-hemolysin (Hlb), known to promote skin colonization. However, its direct involvement in skin inflammation is unclear. In this study, we identified that Hlb activated the epidermal growth factor receptor (EGFR) to induce skin inflammation, through its sphingomyelinase activity. We found that Hlb...

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PMID: 38059627
DOI: 10.1128/spectrum.02227-23

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