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Article

The Janus face of α-toxin: a potent mediator of cytoprotection in staphylococci-infected macrophages.

Journal of innate immunity - 1 Jan 2015

Koziel Joanna, Chmiest Daniela, Bryzek Danuta, Kmiecik Katarzyna, Mizgalska Danuta, Maciag-Gudowska Agnieszka, Shaw Lindsey N, Potempa Jan

Abstract excerpt

After phagocytosis by macrophages, Staphylococcus aureus evades killing in an α-toxin-dependent manner, and then prevents apoptosis of infected cells by upregulating expression of antiapoptotic genes like MCL-1 (myeloid cell leukemia-1). Here, using purified α-toxin and a set of hla-deficient strains, we show that α-toxin is critical for the induction of MCL-1 expression and the cytoprotection of infected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25358860
DOI: 10.1159/000368048
PMCID: PMC4348342

Genes

TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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