Article
Staphylococcal Superantigen-Like Protein 10 (SSL10) induces necroptosis through TNFR1 activation of RIPK3-dependent signal pathways
2021-05-05
Abstract excerpt
Staphylococcal aureus ( S. aureus ) infection can lead to a wide range of diseases such as sepsis and pneumonia. Staphylococcal superantigen like (SSL) proteins, specifically expressed by S. aureus , are shown to be involved in immune evasion during S. aureus infection. Here, we show that SSL10, an SSL family protein, exhibits potent cytotoxicity against human cells (HEK 293T and HUVEC) by inducing necroptosis upo...
Topics
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- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Clostridium difficile and Clostridium perfringens research
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Streptococcal Infections and Treatments
- T-cell and B-cell Immunology
- Toxin Mechanisms and Immunotoxins
Identifiers and source
- Literature Corpus work
- cac3e110-2661-5f48-a911-8514950d8e64
- DOI
- 10.21203/rs.3.rs-445262/v1
