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Deciphering the Pathological Role of Staphylococcal α-Toxin and Panton–Valentine Leukocidin Using a Novel Ex Vivo Human Skin Model

8 May 2018

Abstract excerpt

alpha-toxin and Panton-Valentine leukocidin (PVL) have been reported to play critical roles in different animal models of skin infection. These models, however, do not completely recapitulate the human disease due to the host specificity of these toxins as well as the intrinsic anatomical and immunological differences between animals and humans. Human skin explants represent a valid alternative to animal models...

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PMID: 29867940
DOI: 10.3389/fimmu.2018.00951

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