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Article

Ni(II) coordination to mixed sites modulates DNA binding of HpNikR via a long-range effect.

Proceedings of the National Academy of Sciences of the United States of America - 10 Apr 2012

West Abby L, Evans Sarah E, González Javier M, Carter Lester G, Tsuruta Hiro, Pozharski Edwin, Michel Sarah L J

Abstract excerpt

Helicobacter pylori NikR (HpNikR) is a nickel-dependent transcription factor that regulates multiple genes in the H. pylori pathogen. There are conflicting data regarding the locations of the Ni(II) sites and the role of Ni(II) coordination in DNA recognition. Herein, we report crystal structures of (i) the metal-binding domain (MBD) of HpNikR (3.08 Å) and (ii) a mutant, H74A (2.04 Å), designed to disrupt native...

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Identifiers

PMID: 22451934
DOI: 10.1073/pnas.1120283109
PMCID: PMC3326501

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