Article
Acid-induced activation of the urease promoters is mediated directly by the ArsRS two-component system of Helicobacter pylori.
Infection and immunity - 1 Oct 2005
Pflock Michael, Kennard Simone, Delany Isabel, Scarlato Vincenzo, Beier Dagmar
Abstract excerpt
The nickel-containing enzyme urease is an essential colonization factor of the human gastric pathogen Helicobacter pylori which enables the bacteria to survive the low-pH conditions of the stomach. Transcription of the urease genes is positively controlled in response to increasing concentrations of nickel ions and acidic pH. Here we demonstrate that acid-induced transcription of the urease genes is mediated...
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