Intake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C.

doi:10.1194/jlr.P023721

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Article

Intake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C.

Journal of lipid research - 1 Jun 2012

Hellstrand S, Sonestedt E, Ericson U, Gullberg B, Wirfält E, Hedblad B, Orho-Melander M

Abstract excerpt

Polymorphisms of the FA desaturase (FADS) gene cluster have been associated with LDL, HDL, and triglyceride concentrations. Because FADS converts α-linolenic acid (ALA) and linoleic acid into PUFAs, we investigated the interaction between different PUFA intakes and the FADS polymorphism rs174547 (T>C) on fasting blood lipid and lipoprotein concentrations. We included 4,635 individuals (60% females, 45-68 years)...

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PMID: 22451038
DOI: 10.1194/jlr.P023721
PMCID: PMC3351825

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Intake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C.PMID 22451038Read ↗

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