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Article

Intake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C.

Journal of lipid research - 1 Jun 2012

Hellstrand S, Sonestedt E, Ericson U, Gullberg B, Wirfält E, Hedblad B, Orho-Melander M

Abstract excerpt

Polymorphisms of the FA desaturase (FADS) gene cluster have been associated with LDL, HDL, and triglyceride concentrations. Because FADS converts α-linolenic acid (ALA) and linoleic acid into PUFAs, we investigated the interaction between different PUFA intakes and the FADS polymorphism rs174547...

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Source

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Identifiers

PMID: 22451038
DOI: 10.1194/jlr.P023721
PMCID: PMC3351825

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22451038-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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Intake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C.PMID 22451038Read ↗

Dietary linoleic acid interacts with FADS1 genetic variability to modulate HDL-cholesterol and obesity-related traits.Semantic proximity Read ↗

FADS1 genetic variability interacts with dietary α-linolenic acid intake to affect serum non-HDL-cholesterol concentrations in European adolescents.Semantic proximity Read ↗

FADS1 rs174550 genotype and high linoleic acid diet modify plasma PUFA phospholipids in a dietary intervention study.Semantic proximity Read ↗

The FADS1 rs174550 Genotype Modifies the n-3 and n-6 PUFA and Lipid Mediator Responses to a High Alpha-Linolenic Acid and High Linoleic Acid Diets.Semantic proximity Read ↗

Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study.Semantic proximity Read ↗

Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease.Semantic proximity Read ↗

The FADS1 Genotype Modifies Metabolic Responses to the Linoleic Acid and Alpha-linolenic Acid Containing Plant Oils-Genotype Based Randomized Trial FADSDIET2.Semantic proximity Read ↗

Association between FADS1 rs174547 and levels of long-chain PUFA: a meta-analysis.Semantic proximity Read ↗

Interaction among dietary n-3 and n-6 polyunsaturated fatty acid intake, fatty acid desaturase 2 genetic variants, and low-density lipoprotein cholesterol levels in type 2 diabetes patients.Semantic proximity Read ↗

Interaction between a common variant in FADS1 and erythrocyte polyunsaturated fatty acids on lipid profile in Chinese Hans.Semantic proximity Read ↗

FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on HealthSemantic proximity Read ↗

Serum Lipid Concentrations and FADS Genetic Variants in Young Mexican College Students: The UP-AMIGOS Cohort Study.Semantic proximity Read ↗

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