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Article

Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease.

The Journal of nutrition - 1 Sept 2014

Hellstrand Sophie, Ericson Ulrika, Gullberg Bo, Hedblad Bo, Orho-Melander Marju, Sonestedt Emily

Abstract excerpt

The unclear link between intake of polyunsaturated fatty acids (PUFAs) and risk of cardiovascular disease (CVD) could depend on genetic differences between individuals. Minor alleles of single-nucleotide polymorphisms (SNPs) in the ∆5 fatty acid desaturase (FADS) 1 gene were associated with lower...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25008580
DOI: 10.3945/jn.114.192708
PMCID: PMC4130826

Genes

FADS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25008580-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Genetic variation in FADS1 has little effect on the association between dietary PUFA intake and cardiovascular disease.PMID 25008580Read ↗

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The impact of fatty acid desaturase genotype on fatty acid status and cardiovascular health in adults.Semantic proximity Read ↗

FADS1 genetic variability interacts with dietary α-linolenic acid intake to affect serum non-HDL-cholesterol concentrations in European adolescents.Semantic proximity Read ↗

Intake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C.Semantic proximity Read ↗

Association between FADS1 rs174547 and levels of long-chain PUFA: a meta-analysis.Semantic proximity Read ↗

Identification of a functional FADS1 3'UTR variant associated with erythrocyte n-6 polyunsaturated fatty acids levels.Semantic proximity Read ↗

FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.Semantic proximity Read ↗

Dietary n-3 polyunsaturated fatty acid intakes modify the effect of genetic variation in fatty acid desaturase 1 on coronary artery disease.Semantic proximity Read ↗

FADS2 Variants are Associated with Omega-6 Metabolic Conversion in Serbian Adults in a cross-sectional study – Implications for Precision Nutrition PracticeSemantic proximity Read ↗

Association of polymorphisms in FADS gene with age-related changes in serum phospholipid polyunsaturated fatty acids and oxidative stress markers in middle-aged nonobese men.Semantic proximity Read ↗

FADS1 and FADS2 Polymorphisms Modulate Fatty Acid Metabolism and Dietary Impact on HealthSemantic proximity Read ↗

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