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Article

Computational analysis of adaptive antigenic mutations of the human influenza hemagglutinin for vaccine strain selection.

International journal of bioinformatics research and applications - 1 Jan 2012

Rickert Jared D, Herpy Todd A, Zhong Haizhen, Lu Guoqing

Abstract excerpt

The adaptive evolution of the hemagglutinin (HA) segment of the human influenza H1N1 and H3N2 viruses is not well understood due to antigenic mutations under selection pressures. This paper identified significant antigenic selection sites and discussed the structural relevance of these mutations. We discovered four positively selected sites for H1N1 (position 206 for the 1A lineage - 2009 swine influenza, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22450272
DOI: 10.1504/IJBRA.2012.045978

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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