Article
Co-occurrence of BAP1 and SF3B1 mutations in uveal melanoma induces cellular senescence.
Molecular oncology - 1 Feb 2022
Yu Le, Zhou Dan, Zhang Guiming, Ren Zhonglu, Luo Xin, Liu Peng, Plouffe Steven W, Meng Zhipeng, Moroishi Toshiro, Li Yilei, Zhang Yiyue, Brown Joan Heller, Liu Shuwen, Guan Kun-Liang
Abstract excerpt
Uveal melanoma (UM) is the most common intraocular tumor in adults. Recurrent mutations in BRCA1-associated protein 1 (BAP1) and splicing factor 3B subunit 1 (SF3B1) display a mutually exclusive pattern in UM, but the underlying mechanism is unknown. We show that combined BAP1 deficiency and SF3B1 hotspot mutation lead to senescence and growth arrest in human UM cells. Although p53 protein expression is induced,...
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