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Article

Genome-wide aberrant methylation in primary metastatic UM and their matched metastases

7 Jan 2022

Abstract excerpt

Uveal melanoma (UM) is an aggressive intra-ocular cancer with a strong tendency to metastasize. Metastatic UM is associated with mutations in BAP1 and SF3B1, however only little is known about the epigenetic modifications that arise in metastatic UM. In this study we aim to unravel epigenetic changes contributing to UM metastasis using a new genome-wide methylation analysis technique that covers over 50% of all...

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PMID: 34997020
DOI: 10.1038/s41598-021-03964-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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