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Article

BAP1 deficiency causes loss of melanocytic cell identity in uveal melanoma.

BMC cancer - 5 Aug 2013

Matatall Katie A, Agapova Olga A, Onken Michael D, Worley Lori A, Bowcock Anne M, Harbour J William

Abstract excerpt

BACKGROUND: Uveal melanoma is a highly aggressive cancer with a strong propensity for metastasis, yet little is known about the biological mechanisms underlying this metastatic potential. We recently showed that most metastasizing uveal melanomas, which exhibit a class 2 gene expression profile, contain inactivating mutations in the tumor suppressor BAP1. The aim of this study was to investigate the role of BAP1...

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Share to Heterografts
Share to Host Cell Factor C1
Share to Melanocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplastic Stem Cells

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Source

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Identifiers

PMID: 23915344
DOI: 10.1186/1471-2407-13-371
PMCID: PMC3846494

Genes

BAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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