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Article

Common NOD2 risk variants in African Americans with Crohn's disease are due exclusively to recent Caucasian admixture.

Inflammatory bowel diseases - 1 Dec 2012

Adeyanju Oloruntosin, Okou David T, Huang Clifton, Kumar Archana, Sauer Cary, Galloway Courtney, Prasad Mahadev, Waters Jon, Cutler David J, Zwick Michael E, Dhere Tanvi, Kugathasan Subra

Abstract excerpt

BACKGROUND: Crohn's disease (CD) is highly heritable. NOD2 has emerged as the main susceptibility gene among individuals of European ancestry; however, NOD2 does not appear to contribute to CD susceptibility among many non-European populations. Today's African American (AA) population represents an admixture of West African (80%) and European (20%) ancestry. Since genotype-based tools are becoming increasingly...

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Source

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Identifiers

PMID: 22447396
DOI: 10.1002/ibd.22944
PMCID: PMC3392535

Genes

NOD2

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