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Article

Squelching of ETS2 transactivation by POU5F1 silences the human chorionic gonadotropin CGA subunit gene in human choriocarcinoma and embryonic stem cells.

Molecular endocrinology (Baltimore, Md.) - 1 May 2012

Gupta Rangan, Ezashi Toshihiko, Roberts R Michael

Abstract excerpt

The subunit genes encoding human chorionic gonadotropin, CGA, and CGB, are up-regulated in human trophoblast. However, they are effectively silenced in choriocarcinoma cells by ectopically expressed POU domain class 5 transcription factor 1 (POU5F1). Here we show that POU5F1 represses activity of the CGA promoter through its interactions with ETS2, a transcription factor required for both placental development...

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Source

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Identifiers

PMID: 22446105
DOI: 10.1210/me.2011-1146
PMCID: PMC3355552

Genes

CGA
ETS2
DLX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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