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Article

Transcriptional Regulation of the Human Chorionic Gonadotropin β Gene during Villous Trophoblast Differentiation

12 Jan 2004

Abstract excerpt

Expression of the trophoblast-specific subunit of human chorionic gonadotropin, CGbeta, is associated with fusion of cytotrophoblasts into a multinuclear syncytium. Here, we studied regulation of the CGbeta5 gene in trophoblasts undergoing in vitro syncytialization. Transfection of luciferase reporters harboring different lengths of the CGbeta5 upstream sequence revealed that the proximal promoter region (-345 to...

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PMID: 14715707
DOI: 10.1210/en.2003-0954

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