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Article

Hesx1 homeodomain protein represses transcription as a monomer and antagonises transactivation of specific sites as a homodimer.

Journal of molecular endocrinology - 1 Jun 2002

Quirk J, Brown P

Abstract excerpt

The homeobox repressor Hesx1, expressed throughout Rathke's pouch and required for normal pituitary development, has been implicated in anterior pituitary pathogenesis in man. Prolonged expression of Hesx1 delays the appearance of anterior pituitary terminal differentiation markers in mice, particularly the gonadotroph hormones. We tested if Hesx1 could modulate gonadotrophin gene expression directly, and found...

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Source

Identifiers

PMID: 12063185
DOI: 10.1677/jme.0.0280193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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